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Honoring the Gift
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The IIAM Journal
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A Gift that Keeps
on Giving

Testimonials from Researchers:
  • "IIAM's flexibility and dedication has allowed us to work on projects investigating the safety and efficacy of over 300 potential new drugs. We would not have achieved this without the professionalism of the team at IIAM and their understanding of our needs as researchers. Human tissue research really isn’t an easy area of science, but the team at IIAM try to alleviate the difficulty for the end researcher. We look forward to continuing to expand the applications of human tissue and together with IIAM believe we are making a real impact on the quality of medicines entering clinical trials."

  • "My company has realised the value of access to human tissue for a while now but getting hold of good quality tissue easily has been problematic. Therefore, the service that IIAM provides is a huge step forward. We have used the human lung material received from IIAM to aid our drug discovery research by studying the biological role and disease relevance of proteins that may be of therapeutic relevance in lung disease. For instance, we were able to gain valuable insights on a receptor found on macrophages that we are interested in. Most work on this receptor has been done in mice, so there was very little data available on human lung. The value that the material has added to respiratory research in my company has been recognised in other disease areas and as a result, my company has set up a larger agreement with IIAM. So IIAM tissue will become used for research on a number of different diseases. IIAM provides a very valuable service and is helping the discovery of new drugs in my company."

  • "Donated human tissue is used in our in vitro drug permeation and metabolism models to study specific biological mechanisms involved in the absorption and disposition of drugs and to predict potential drug-drug interactions that could affect the safety of a new drug once it reaches the clinic. We are thankful to IIAM recovery and administrative teams for helping us to meet our research objectives and look forward to continue our partnership in 2011."

  • "The urinary bladder studies have allowed us to uncover a diversity of contractile responses and confirm the interaction between the urothelium and the underlying muscle layer that previously was only postulated to occur in humans based on animal studies. For the Gastro-esophageal junction studies there are very few animal models that have the same muscle fiber anatomy as the human and these are somewhat difficult to obtain for research purposes. Our continuing studies allow us to make important observations that help explain the functional studies performed using high resolution manometry coupled with high resolution ultrasonography and are beginning to provide insight into the mechanisms behind the events that cause gastro esophageal reflux disease."

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